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Zactima
aka vandetanib, ZD-6474 is Astra’s Vegf / EGF doublet inhbitor. wiki, clinic, WO/2001/032651
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WO/2007/071955
Title’d app is from AstraZeneca and has ’bout 82 thiazoles said to hit c-Fms. click for the guess
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AZ’s GSK3 Indolinone
WO/2007/089192 is a use app, and WO/2007/089191 is salt forms application of the pictured GSK3 inhibitor originally from WO/2003/08285. The YM-231146 / YM-359445 series bears similarity, albeit for...
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AZ’s Bis-Morpholine
+ XRPD on multiple salt forms of this EphB4 inhibitor: WO/2008/104754
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AZD-7762
It’s going ph1, it’s from WO/2005/066163, and it’s been described. Somebody send it to Ambit. XL-844, PF-477736, IC-83 are the known competition. Posted in Astra, Chk1
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Astra’s got IGF1R
Its not in the pipeline, but it is a candidate. WO/2008/117051 has xrpd, and lots of data. 10x enough? ‘o’; mode Posted in Astra, IGF
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AZ: More GSK3
Likely backup series. Pictured: WO/2008/121064, and similar WO/2008/121063 Previously… Posted in Astra, GSK3
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ARRY-704 ?
aka ARRY-424704 / AZD-8330 is the Array / Astra Mek Ph1 backup to ARRY-886 / AZD-6244 which was put in a holding pattern when it didn’t meet a ph2 endpoint. The pictured strucuture is ‘Mek Inhibitor...
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MK n AZ
Two allosteric inhibitors are better then one! AZD-6244 is Array’s MEK inhibitor [ARRY-886] which failed a solo ph2 endpoint not too long ago. MK-2206 is Merck’s ph1 AKT inhibitor Posted in Array,...
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